Recent calls for knowledge-based journalism advocate a new level of formal knowledge in news reporting to meet the professional challenges caused by rapid change in the news industry. Scientifically knowledgeable journalism has the potential to redefine the existing science–media relationship. However, the audience for such journalism is unclear, nor is it known how this new journalism would function within rapidly changing newsroom practices. Implementing knowledge-based journalism requires theory-based propositions to show the actual benefits of improved scientific understanding for news consumers and an understanding, from research into professional cultures, of why new practices in journalism are adopted or abandoned. This paper develops that theoretical basis by examining knowledge-based journalism’s potential and some of the intellectual and institutional barriers to it.