Title
The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
Date Issued
08 May 2018
Access level
open access
Resource Type
review
Author(s)
Sychev D.A.
Ashraf G.M.
Svistunov A.A.
Maksimov M.L.
Tarasov V.V.
Chubarev V.N.
Otdelenov V.A.
Denisenko N.P.
Aliev G.
Universidad Autónoma de Chile
Publisher(s)
Dove Medical Press Ltd.
Abstract
Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I biotransformation. The most important role in biotransformation belongs to CYP3A4, CYP2D6, CYP2C9, CYP2C19 and CYP1A2. Inhibition and induction of CYP isoenzymes caused by drugs are important and clinically relevant pharmacokinetic mechanisms of drug interaction. Investigation of the activity of CYP isoenzymes by using phenotyping methods (such as the determination of the concentration of specific substrates and metabolites in biological fluids) during drug administration provides the prediction of negative side effects caused by drug interaction. In clinical practice, the process of phenotyping of CYP isoenzymes and some endogenous substrates in the ratio of cortisol to 6β-hydroxycortisol in urine for the evaluation of CYP3A4 activity has been deemed to be a quite promising, safe and minimally invasive method for patients nowadays.
Start page
1147
End page
1156
Volume
12
Language
English
OCDE Knowledge area
Farmacología, Farmacia
Biotecnología médica
Scopus EID
2-s2.0-85046669972
PubMed ID
Source
Drug Design, Development and Therapy
ISSN of the container
11778881
Sponsor(s)
Gjumrakch Aliev’s work was supported by a grant from the Russian Science Foundation (directed design, synthesis and study of biological activity of multitarget compounds as innovative drugs for the treatment of neurodegenerative diseases: PHΦ 14-23-00160Π). Gjumrakch Aliev is also grateful for the equipment of Center for Collective Use, Institute of Physiologically Active Compounds of Russian Academy of Sciences Chernogolovka, Russia, that was used for this review.
Sources of information:
Directorio de Producción Científica
Scopus