This study evaluates the influence of the Hazen-Williams and Darcy-Weisbach methods on the hydraulic balance of a mine pumping system. Underground mining companies use pumping stations for evacuate the produced water. Designers and equipment sellers use different expressions to estimate the head loss. This study analyzes and validates the implementation of some of these expressions to a mine pumping system. The features of the case study are: water flow rate of 1350 l/s, steel and HDPE diameter pipes of 16 in. and 18 in., respectively. The total pipe length is 2900 m, and the hydraulic height difference is 230 m. The calculations were performed by the above-mention methods, taking the expressions of Haaland, Swamee-Jain and Churchill for friction factors. The results were compared with those measured in field, taking a maximum deviation of system of 28.6% and 3.1% for head loss and total head, respectively.