Mauritia flexuosa L.f. is a palm from the Amazon. Pulp and oil are extracted from its fruits, with a high content of bioactive compounds. This study presents the economic evaluation of two extraction processes: (a) Conventional solvent extraction (CSE) with 80% ethanol for the recovery of phenolic-rich extracts; and (b) Supercritical fluid extraction (SFE) followed by CSE to obtain oil and phenolic-rich extracts. The objective of this study was to compare the feasibility of both extraction processes. The economic evaluation and the sensitivity study were evaluated using the SuperPro Designer 9.0® software at an extraction volume of 2000 L. Similar global extraction yields were obtained for both processes; however, 8.4 and 2.4 times more total polyphenol and flavonoid content were extracted, respectively, using SFE+CSE. Cost of manufacturing (COM) was higher in SFE+CSE compared to CSE, USD 193.38/kg and USD 126.47/kg, respectively; however, in the first process, two by-products were obtained. The sensitivity study showed that the cost of the raw material was the factor that had the highest impact on COM in both extraction processes. SFE+CSE was the most economically viable process for obtaining bioactive compounds on an industrial scale from M. flexuosa L.f.