In this paper, computational intelligence technique are presented for solving multi-point nonlinear boundary value problems based on artificial neural networks, evolutionary computing approach, and active-set technique. The neural network is to provide convenient methods for obtaining useful model based on unsupervised error for the differential equations. The motivation for presenting this work comes actually from the aim of introducing a reliable framework that combines the powerful features of ANN optimized with soft computing frameworks to cope with such challenging system. The applicability and reliability of such methods have been monitored thoroughly for various boundary value problems arises in science, engineering and biotechnology as well. Comprehensive numerical experimentations have been performed to validate the accuracy, convergence, and robustness of the designed scheme. Comparative studies have also been made with available standard solution to analyze the correctness of the proposed scheme. © 2014 Growing Science Ltd. All rights reserved.