The aim was to determine the relationship between organizational climate and professional performance of the administrative staff of a Peruvian state university. The sample was comprised of 202 administrative workers and the questionnaire was used as an instrument to collect data. A non-experimental, cross-sectional design was used. The applied data analysis and processing techniques were descriptive and inferential, such as the arithmetic mean, the standard deviation, the student’s “t” and the Pearson correlation test. The results were that: The relationship between the organizational climate and the professional performance of the administrative staff of a Peruvian state university is significant; The relationship between the motivation and the work initiative of the administrative staff of a Peruvian state university is significant; and that there is a significant level of relationship between human relations and the responsibility in the performance of functions of the administrative staff of a Peruvian state university. It was concluded that there is a great intention and feeling of sharing personal objectives with those of the organization, which denotes that an efficient organizational climate an adequate professional performance and a poor organizational climate an inadequate professional performance.