The Manufacturing cell design problem focuses on the creation of an optimal distribution of the machinery on a productive plant, through the creation of highly independent cells where the parts of certain products are processed. The main objective is to reduce the movements between this cells, decreasing production times, costs and getting other advantages. To find solutions to this problem, in this paper, the usage of the Flower Pollination Algorithm is proposed, which is one of the many nature-based algorithms, which in this case is inspired in the Pollination of the flowers, and has shown great capacities in the resolution of complex problems. Experimental results are shown, with 90 instances taken from Boctor’s experiments, where the optimum is achieved in all them.