Title
Bayesian inference in nonlinear mixed-effects models using normal independent distributions
Date Issued
01 August 2013
Access level
metadata only access
Resource Type
journal article
Author(s)
Lachos V.H.
Dey D.K.
Universidad de Concepción
Publisher(s)
Elsevier B.V.
Abstract
Nonlinear mixed-effects (NLME) models are popular in many longitudinal studies, including those on human immunodeficiency virus (HIV) viral dynamics, pharmacokinetic analysis, and studies of growth and decay analysis. Generally, the normality of the random effects is a common assumption in NLME models but it can sometimes be unrealistic, suppressing important features of among-subjects variation. In this context, the use of normal/independent distributions arises as a tool for robust modeling of NLME models. These distributions fall in a class of symmetric heavy-tailed distributions that includes the normal distribution, the generalized Student-t, Student-t, slash and the contaminated normal distributions as special cases, providing an appealing robust alternative to the routine use of normal distributions in these types of models. The aim of this paper is the estimation of NLME models considering normal/independent distributions for the error term and random effects, under the Bayesian paradigm. A Bayesian case deletion influence diagnostic based on the q-divergence measure and model selections criteria is also developed. These analyses are computationally possible due to an important result that approximates the likelihood function of a NLME model with normal/independent distributions for a simple normal/independent distribution with specified parameters. An example of the new method is presented through simulation and application to a real dataset of AIDS/HIV infected patients that was initially analyzed using a normal NLME model.
Start page
237
End page
252
Volume
64
Language
English
OCDE Knowledge area
Estadísticas, Probabilidad Sociología
Scopus EID
2-s2.0-84874736780
Source
Computational Statistics and Data Analysis
ISSN of the container
01679473
Sponsor(s)
We thank the Editor, Associate Editor and two referees whose constructive comments led to a much improved presentation. V.H. Lachos acknowledges support from CNPq-Brazil (Grant 305054/2011-2 ) and from FAPESP-Brazil (Grant 2011/17400-6 ). The research of L.M. Castro is supported by FONDECYT (Grant 1130233 ) from the Chilean government.
Sources of information: Directorio de Producción Científica Scopus