Title
MOCOnet: Robust Motion Correction of Cardiovascular Magnetic Resonance T1 Mapping Using Convolutional Neural Networks
Date Issued
01 January 2021
Access level
open access
Resource Type
journal article
Author(s)
Zhang Q.
Papież B.W.
Werys K.
Lukaschuk E.
Popescu I.A.
Burrage M.K.
Shanmuganathan M.
Ferreira V.M.
Piechnik S.K.
University of Oxford
Publisher(s)
Frontiers Media S.A.
Abstract
Background: Quantitative cardiovascular magnetic resonance (CMR) T1 mapping has shown promise for advanced tissue characterisation in routine clinical practise. However, T1 mapping is prone to motion artefacts, which affects its robustness and clinical interpretation. Current methods for motion correction on T1 mapping are model-driven with no guarantee on generalisability, limiting its widespread use. In contrast, emerging data-driven deep learning approaches have shown good performance in general image registration tasks. We propose MOCOnet, a convolutional neural network solution, for generalisable motion artefact correction in T1 maps. Methods: The network architecture employs U-Net for producing distance vector fields and utilises warping layers to apply deformation to the feature maps in a coarse-to-fine manner. Using the UK Biobank imaging dataset scanned at 1.5T, MOCOnet was trained on 1,536 mid-ventricular T1 maps (acquired using the ShMOLLI method) with motion artefacts, generated by a customised deformation procedure, and tested on a different set of 200 samples with a diverse range of motion. MOCOnet was compared to a well-validated baseline multi-modal image registration method. Motion reduction was visually assessed by 3 human experts, with motion scores ranging from 0% (strictly no motion) to 100% (very severe motion). Results: MOCOnet achieved fast image registration (<1 second per T1 map) and successfully suppressed a wide range of motion artefacts. MOCOnet significantly reduced motion scores from 37.1±21.5 to 13.3±10.5 (p < 0.001), whereas the baseline method reduced it to 15.8±15.6 (p < 0.001). MOCOnet was significantly better than the baseline method in suppressing motion artefacts and more consistently (p = 0.007). Conclusion: MOCOnet demonstrated significantly better motion correction performance compared to a traditional image registration approach. Salvaging data affected by motion with robustness and in a time-efficient manner may enable better image quality and reliable images for immediate clinical interpretation.
Volume
8
Language
English
OCDE Knowledge area
Neurociencias
Sistema cardiaco, Sistema cardiovascular
Radiología, Medicina nuclear, Imágenes médicas
Subjects
Scopus EID
2-s2.0-85127613458
Source
Frontiers in Cardiovascular Medicine
ISSN of the container
2297055X
Sponsor(s)
RG acknowledges support for his D.Phil. studies from the Clarendon Fund, the Balliol College and the Radcliffe Department of Medicine, University of Oxford. QZ, VF, and SP acknowledge John Fell Oxford University Press Research Fund. QZ, MB, VF, and SP acknowledge support from the Oxford BHF Centre of Research Excellence (RE/18/3/34214). BP acknowledges Rutherford Fund at Health Data Research UK (MR/S004092/1). MB is supported by a British Heart Foundation (BHF) Clinical Research Training Fellowship (FS/19/65/34692). MS is supported by the Alison Brading Memorial Graduate Scholarship in Medical Science, Lady Margaret Hall, University of Oxford. IP, MB, VF, and SP acknowledge support from the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre at The Oxford University Hospitals NHS Foundation Trust.
Sources of information:
Directorio de Producción Científica
Scopus