Introduction: The objective of this research was to determine the influence of family structure and function on the resilience of people with physical and sensory disabilities in the city of Arequipa (Peru). Method: We assessed 240 people with physical and sensory disabilities; their age was between 12 and 61 years. The Family Social Climate Scale (FES), the Family System Assessment Scale (FACES III), and the Wagnild and Young Resilience Scale, an ad-hoc family structure and a sociodemographic data questionnaire were applied. The method used was quantitative, not experimental and predictive. Results: We found that family functioning variables such as cohesion and adaptability; in addition to having economic support and own work are predictive factors of higher levels of resilience. While factors such as sex, cause of disability, sociodemographic problems and family structure do not affect the levels of resilience of the person with physical and sensory disability. Conclusion: We conclude that family and socio-labor variables have a significant impact on the levels of resilience of people with physical and sensorial disabilities.