In this paper a hybrid metaheuristic for biclustering based on Scatter Search and Genetic Algorithms is presented. A general scheme of Scatter Search has been used to obtain high-quality biclusters, but a way of generating the initial population and a method of combination based on Genetic Algorithms have been chosen. Experimental results from yeast cell cycle and human B-cell lymphoma are reported. Finally, the performance of the proposed hybrid algorithm is compared with a genetic algorithm recently published. © 2009 Springer Berlin Heidelberg.