Electronic health (eHealth) requires a multidisciplinary approach and involves different areas of knowledge, including medicine, computer science, engineering, sociology, anthropology, social work, administration, law, and communication sciences. The assessment of eHealth should consider that information and communication technologies (ICTs) are only part of the information system of an organization. Understanding the human factors involved in health systems, the environment, and the contexts in which ICTs are used in health is essential. The objectives of this study were to describe the status of the assessment of eHealth in Peru and to discuss the strategies for multidisciplinary evaluation that should be considered to achieve the success and sustainability of these initiatives based on national and international experience.