Objective. This correlational descriptive cross-sectional study was conducted to determine the level of knowledge and its relationship with attitudes and Zika's preventive practices in the district of Chepen, La Libertad, Peru, 2017. Materials and methods. A questionnaire on knowledge, attitudes and preventive practices was applied to a sample of 284 adult persons, with an average age of 37 years. Results. The results showed that the level of general knowledge about zika was regular at 79% and good at 21%. As for the most common zika's preventive practices carried out by the inhabitants of Chepén, 83% mentioned that they frequently washed their water tanks, 77% used a brush and detergent to wash the tanks with water and 75% placed a lid over the tanks with water. Conclusions. There is a significant relationship between level of knowledge and sika's preventive practices (p < 0.05).In addition, regular knowledge is a risk factor (OR: 5, CI: 2.073-10.063) for inadequate zika's preventive practice; people with regular knowledge are 5 times more likely to have inadequate preventive practices. However, the level of knowledge does not have a significant relationship with attitudes towards the prevention of zika (p > 0.05).