The main objective of the current study is to propose a methodology for implementation of a Cleaner Production program at the campus of the National University of Engineering in Lima, Peru. Documentation review was carried out with regard to principles and applications of Cleaner Production, identifying strategies associated with its implementation in processes, products, and services. A university campus was characterized, being the target of the present study, as a mix of processes with entries, operations, and outputs related to the distinct schools and departments. Relevant usages and consumptions of electricity, fuels, water, and paper were identified among others. Also, guidelines for further recollection of quantitative data as well as the unit costs of their utilization were established. A methodology for implementation of a Cleaner Production program at a university campus was elaborated on the basis of five general steps: 1) Planning and Organization, 2) Diagnostic, 3) Feasibility Study, 4) Implementation and Monitoring, and 5) Continuous Improvement.