Title
Pollen-Based Magnetic Microrobots are Mediated by Electrostatic Forces to Attract, Manipulate, and Kill Cancer Cells
Date Issued
01 January 2022
Access level
metadata only access
Resource Type
journal article
Author(s)
Fojtů M.
Vyskočil J.
Cho N.J.
Pumera M.
University of Chemistry and Technology Prague
Publisher(s)
John Wiley and Sons Inc
Abstract
Naturally occurring micro/nanoparticles provide an incredible array of potential sources when preparing hybrid micro/nanorobots and their intrinsic properties can be exploited as multitasking functionalities of modern robotics as well as ensuring their mass production availability. Herein, magnetic biological bots (BioBots) prepared from defatted sunflower pollen microparticles by ferromagnetic metal layer evaporation on one side of its surface are described. It is demonstrated that the methodology employed introduces magnetic properties to sunflower pollen microparticles-based BioBots and enable their magnetic actuation. Interestingly, as-prepared magnetic sunflower pollen-based BioBots can naturally attract cancer cells due to their opposite charges (positive and negative, respectively). Such attracted cancer cells can then be transported by microrobots. This strong attraction also allows the delivery of drugs intended to kill the cancer cells. Sunflower-based BioBots can be fabricated in large quantities, and are naturally programmable, making them promising candidates for cancer cell therapy.
Language
English
OCDE Knowledge area
Nano-tecnología
Scopus EID
2-s2.0-85137337611
Source
Advanced Functional Materials
Resource of which it is part
Advanced Functional Materials
ISSN of the container
1616301X
Source funding
European Research Council
Sponsor(s)
This work was supported by the project “Advanced Functional Nanorobots” (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR), the Ministry of Health of the Czech Republic (NU21‐08‐00407), and Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under ERC CZ program.
Sources of information: Directorio de Producción Científica Scopus