Leptospirosis is a disease classified as zoonotic, and it is also one of the most neglected. As an endemic zoonotic disease, it remains in the least favored places, affecting human health and also that of certain domestic animals. Such damage causes substantial economic and health losses in vulnerable populations. The incidence is estimated to affect one million human beings, causing the death of almost 59,000 of them. Transmission of human leptospirosis is due to direct or indirect exposure to primary infection sources such as infected animals (urine or tissues), and also by contact with contaminated food or water. In this work, the prevalence and risk factors of leptospirosis in the pig industry in different regions of the Peruvian State were studied. The results showed that workers, mostly male, aged between 20 and 50 years were the most vulnerable to these Leptospira serovars, which is related to direct contact with pigs and their derivatives. On the other hand, the living conditions of the workers influence the higher prevalence of this servar. Rural conditions, lack of hygiene, contact with untreated pets are risk factors for the spread of leptospirosis.