Title
Early Warning of COVID-19 in Tokyo Via Wastewater-Based Epidemiology: How Feasible It Really Is?
Date Issued
01 January 2021
Access level
open access
Resource Type
journal article
Author(s)
Zhu Y.
Oishi W.
Kitajima M.
Sano D.
Tohoku University
Publisher(s)
Japan Society on Water Environment
Abstract
Amid the ongoing battle against COVID-19, the scientific community has high hope in wastewaterbased epidemiology (WBE). It was not only proposed as a complement to capacity-plagued clinical testing, but also an early warning tool that may enable timely intervention measures. In this study, we developed a wastewater SARS-CoV-2 RNA load model based on the fecal shedding profile of infected individuals. The epidemic data of COVID-19 in the Tokyo metropolitan area were used to perform a simulation to analyze the capability of WBE in providing early warning. The simulation result suggests that under the current settings, WBE is not a feasible approach as the detection limit is too high to provide a warning signal in the early stage of the epidemic. However, it also indicates that if the methodology can be reasonably improved by new experimental practices, optimized sampling strategy, and refined model, the concentration of viral RNA in Tokyo wastewater would exceed the detection limit as early as in April 2020, when Tokyo was being hit by the first wave of COVID-19 outbreak. This early detection may have great social benefit if the detection can be used to facilitate the decision-making process and form epidemic emergency response.
Start page
170
End page
183
Volume
19
Issue
3
Language
English
OCDE Knowledge area
Virología Epidemiología
Scopus EID
2-s2.0-85109153843
Source
Journal of Water and Environment Technology
ISSN of the container
13482165
Sponsor(s)
This research was supported by the Japan Agency for Medical Research and Development (AMED), Japan Program for Infectious Diseases Research and Infrastructure (Global Research Infrastructure) under Grant Number JP20wm0125001.
Sources of information: Directorio de Producción Científica Scopus