Title
Protection from murine cysticercosis by immunization with a parasite cysteine protease
Date Issued
01 October 2006
Access level
metadata only access
Resource Type
journal article
Author(s)
Baylor College of Medicine
Publisher(s)
Elsevier
Abstract
Central nervous system infection by Taenia solium cysts causes neurocysticercosis, a common neurological infection in the Third World. We have previously isolated cysteine proteases from Taenia crassiceps and T. solium. In this study, we immunized BALB/c mice with the purified T. solium cysteine protease and challenged them with Taenia crassiceps. Immunized mice had a 72% reduction in parasite burden compared to mice that received no immunization. Immunized mice developed antigen specific lymphocyte proliferation. These data support further studies of the T. solium cysteine protease as a vaccine candidate. © 2006 Elsevier Masson SAS. All rights reserved.
Start page
2733
End page
2735
Volume
8
Issue
12-13
Language
English
OCDE Knowledge area
Inmunología
Subjects
Scopus EID
2-s2.0-33750622641
PubMed ID
Source
Microbes and Infection
ISSN of the container
12864579
Sponsor(s)
We thank the National Institutes of Health Molecular Parasitology Predoctoral training grant for support of this work and a grant from the US-Mexico Foundation for Science.
Sources of information:
Directorio de Producción Científica
Scopus