Objective: To determine the epidemiological profile of malignant melanoma cases treated at the National Institute for Neoplastic Diseases "Dr. Eduardo Caceres Graziani" (INEN) over the period 1952 to 2008. Study Design: All clinical records with complete data of patients presenting a histopathological diagnosis of malignant melanoma of the oral cavity were reviewed. Data such as age, gender, location, tumor size, disease length, presence of metastasis, treatment received and year of admission recorded. Results: During the study period 97 cases found. The average age of patients was 52.85±1.6 years old mostly between 50 and 59 years old; the predominant gender the female. The most common location the palate and there 58.8% of cases with a tumor size bigger than or equal to 4 cm. The length of the disease in 38.1% of the cases was longer than a year and in great part of the cases (69.1%) there no metastasis. The treatment of choice the surgery plus radiotherapy in 38.1% of the cases. According to the admission date it also noted that the number of cases is increasing. Conclusion: The results of this study demonstrate a late diagnosis and an increasing frequency of this neoplasia in the oral cavity. © Medicina Oral S. L.