Title
Preparation of hollow magnetite microspheres and their applications as drugs carriers
Date Issued
01 January 2012
Access level
open access
Resource Type
journal article
Author(s)
Márquez F.
Herrera G.
Campo T.
Cotto M.
Ducongé J.
Sanz J.
Elizalde E.
Morant C.
University of Puerto Rico
Publisher(s)
Springer New York LLC
Abstract
Hollow magnetite microspheres have been synthesized by a simple process through a templatefree hydrothermal approach. Hollow microspheres were surface modified by coating with a silica nanolayer. Pristine and modified hollow microparticles were characterized by field-emission electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, FT-IR and Raman spectroscopy, and VSM magnetometry. The potential application of the modified hollow magnetite microspheres as a drug carrier was evaluated by using Rhodamine B and methotrexate as model drugs. The loading and release kinetics of both molecules showed a clear pH and temperature dependent profile. © 2012 Marquez et al.
Volume
7
Language
English
OCDE Knowledge area
Nano-materiales
Subjects
Scopus EID
2-s2.0-84860664347
Source
Nanoscale Research Letters
ISSN of the container
1931-7573
Sponsor(s)
The authors gratefully recognize the financial support provided by the Department of Energy through the Massey Chair project at University of Turabo and from the National Science Foundation through the contract CHE-0959334. Financial support from MICINN (Spain) through the grant MAT2010-19804 is also acknowledged. The “Servicio Interdepartamental de Investigación (SIdI)” from Universidad Autónoma de Madrid and “Centro de Microscopía Luis Bru” from Universidad Complutense de Madrid are acknowledged for the use of the FE-SEM and HRTEM facilities. OPP also acknowledges the support from The National Science Foundation under Grant No. HRD 0833112 (CREST program).
Sources of information:
Directorio de Producción Científica
Scopus