Splenic infarction is a rare condition usually associated with systemic conditions. Antiphospholipid syndrome (APS) is an autoimmune condition that can present as abdominal pain due to splenic infarction. We describe a patient with systemic lupus erythematosus, admitted due to acute abdominal pain. Abdominal CT scan showed splenic infarction, and tests for antiphospholipid and anti-β2-glycoprotein I antibodies were positive. The pathophysiology and clinical presentation of splenic infarction associated with APS is discussed, emphasizing the importance of including this entity in the differential diagnosis of abdominal pain of uncertain cause in patients with systemic conditions.