This article analyzes the social life and the economic activities of the Portuguese Clerics and Reli-gious who lived in Lima, between 1580 and 1640. The analysis of interpersonal relationship, like methodo-logic method applied to this study, reveals the heterogeneous character of these individuals, the plurality of their belongings and identifications, and the scope of their relationship in the local sphere and extra-regional. Likewise, that their Clerics and Religious condition did not prevent them to engage in economic activities of the region, and set in -in the case of one of them-into commercial networks of transoceanic reach.