Title
Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
Date Issued
15 July 2022
Access level
open access
Resource Type
journal article
Author(s)
Reynolds C.J.
Pade C.
Gibbons J.M.
Otter A.D.
Lin K.M.
Sandoval D.M.
Pieper F.P.
Butler D.K.
Liu S.
Joy G.
Forooghi N.
Treibel T.A.
Manisty C.
Moon J.C.
Semper A.
Brooks T.
McKnight Á.
Altmann D.M.
Boyton R.J.
Abbass H.
Abiodun A.
Alfarih M.
Alldis Z.
Amin O.E.
Andiapen M.
Artico J.
Augusto J.B.
Baca G.L.
Bailey S.N.L.
Bhuva A.N.
Boulter A.
Bowles R.
Bracken O.V.
O'Brien B.
Bullock N.
Captur G.
Carr O.
Champion N.
Chan C.
Chandran A.
Coleman T.
de Sousa J.C.
Couto-Parada X.
Cross E.
Cutino-Moguel T.
D'Arcangelo S.
Davies R.H.
Douglas B.
Di Genova C.
Dieobi-Anene K.
Diniz M.O.
Ellis A.
Feehan K.
Finlay M.
Fontana M.
Francis S.
Gillespie D.
Gilroy D.
Hamblin M.
Harker G.
Hemingway G.
Hewson J.
Heywood W.
Hickling L.M.
Hicks B.
Hingorani A.D.
Howes L.
Itua I.
Jardim V.
Lee W.Y.J.
Jensen M.
Jones J.
Jones M.
Kapil V.
Kelly C.
Kurdi H.
Lambourne J.
Lloyd A.
Louth S.
Maini M.K.
Mandadapu V.
Mfuko C.
Mills K.
Millward S.
Mitchelmore O.
Moon C.
Moon J.
Murray S.M.
Noursadeghi M.
Palma S.
Parker R.
Patel K.
Pawarova M.
Petersen S.E.
Piniera B.
Rannigan L.
Rapala A.
Richards A.
Robathan M.
Publisher(s)
American Association for the Advancement of Science
Abstract
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
Volume
377
Issue
6603
Language
English
OCDE Knowledge area
Virología
Inmunología
Scopus EID
2-s2.0-85132254530
Source
Science
ISSN of the container
00368075
Sources of information:
Directorio de Producción Científica
Scopus