Objectives. To describe the health-related quality of life (HRQoL) of Venezuelan migrants residing in the cities of Chimbote and Nuevo Chimbote, in Peru, and assess its associated factors. Materials and Methods. Cross-sectional study of 212 Venezuelan migrants recruited by snowball sampling. The QoL was evaluated with the European Quality of Life-5 Dimensions at three levels (EQ-5D-3L). The results were presented descriptively. Linear regressions and Poisson adjusted regressions were used to evaluate the factors associated with QoL. Results. The percentage of participants affected in each QoL dimension was: mobility (1.4%), self-care (0.5%), usual activities (2.4%), pain/discomfort (18.4%), and anxiety/depression (68.9%). As for the QoL Visual Analog Scale (VAS), the median score was 85 (RIC: 70-90). In evaluating the associated factors, it was found that none of the factors was associated with the VAS score or pain/ discomfort. However, the frequency of anxiety/depression was higher in those with higher education (university) level compared to those with secondary education (RR 1.28; 95% CI: 1.03 to 1.60). Conclusions. Venezuelan migrants who participated in the study reported problems in their QoL; more than two-thirds reported anxiety/depression, and one in six experienced pain/discomfort. The frequency of anxiety/depression was higher in those with university-level education.