The systematics of the Andean scorpion genus, Orobothriurus Maury, 1976 (Bothriuridae Simon, 1880), is revised. New locality records, obtained during recent field expeditions, distribution maps, and a key to identification of the 15 known species, are provided. Six new species are described: Orobothriurus calchaqui, n. sp., from northwestern Argentina; Orobothriurus compagnuccii, n. sp., from the central Andes of Argentina; Orobothriurus huascaran, n. sp., from central Peru; Orobothriurus quewerukana, n. sp., from southern Peru and northern Chile; Orobothriurus ramirezi, n. sp., from central Chile; and Orobothriurus tamarugal, n. sp., from northern Chile. The known distribution of Orobothriurus and the altitude record for scorpions are discussed. The world's altitude record for a scorpion, previously reported as 5550 m, is demonstrated to be 4910 m. © 2011 American Museum of Natural History.