Title
(+)-epi-α-bisbolol is the wound-healing principle of Peperomia galioides: Investigation of the in vivo wound-healing activity of related terpenoids
Date Issued
14 November 2001
Access level
metadata only access
Resource Type
journal article
Author(s)
VILLEGAS VILCHEZ, LEON FAUSTINO
Marçalo A.
Martin J.
Hammond G.
VAISBERG WOLACH, ABRAHAM JAIME
Abstract
Bioassay-guided investigation of the ethanol extract of Peperomia galioides using a tensile strength method in mice as a monitor led to the isolation of epi-α-bisabolol (1) (ED50 155 μg/mL). An in vivo healing study of selected commercially available monoterpenoids yielded two bioactive compounds, α-bisabolol (2) and α-terpineol (3) (ED50 of 228 and 240 mg/g mouse, respectively).
Start page
1357
End page
1359
Volume
64
Issue
10
Language
English
OCDE Knowledge area
Ciencias de las plantas, Botánica
Farmacología, Farmacia
Scopus EID
2-s2.0-0034752655
PubMed ID
Source
Journal of Natural Products
ISSN of the container
01633864
Sponsor(s)
National Cancer Institute R15CA056911
Sources of information:
Directorio de Producción Científica
Scopus