Title
Comprehensive Viscoelastic Characterization of Tissues and the Inter-relationship of Shear Wave (Group and Phase) Velocity, Attenuation and Dispersion
Date Issued
01 December 2020
Access level
metadata only access
Resource Type
journal article
Author(s)
Parker K.J.
University of RochesterThe institution will open in a new tab
Publisher(s)
Elsevier Inc.
Abstract
We report shear wave phase and group velocity, dispersion and attenuation in oil-in-gelatin viscoelastic phantoms and in vivo liver data. Moreover, we measured the power law coefficient from each dispersion curve and used it, together with the shear wave velocity, to calculate an approximate value for attenuation that agrees with independent attenuation measurements. Results in phantoms exhibit good agreement for all parameters with respect to independent mechanical measurements. For in vivo data, the livers of 20 patients were scanned. Results were compared with pathology scores obtained from liver biopsies. Across these cases, increases in shear wave dispersion and attenuation were related to increased steatosis score. It was found that shear wave dispersion and attenuation are experimentally linked, consistent with simple predictions based on the rheology of tissues, and can be used individually or jointly to assess tissue viscosity. Thus, this study indicates the possible utility of using shear wave dispersion and attenuation to non-invasively and quantitatively assess steatosis.
Start page
3448
End page
3459
Volume
46
Issue
12
Language
English
OCDE Knowledge area
Física y Astronomía
Física de partículas, Campos de la Física
Subjects
Scopus EID
2-s2.0-85091796415
PubMed ID
Source
Ultrasound in Medicine and Biology
ISSN of the container
03015629
DOI of the container
10.1016/j.ultrasmedbio.2020.08.023
Source funding
Samsung
Sponsor(s)
We are grateful for support from Samsung Medison and for the loan of equipment. We also thank Dr. D. Rubens and Dr. A. Sharma for clinical data acquisition and Dr. Z. Hah for his technical support and suggestions.
Sources of information:
Directorio de Producción Científica
Scopus