Title
Autoimmune hepatitis recurrence after liver transplantation: 15 years experience in Peru
Date Issued
01 January 2018
Access level
metadata only access
Resource Type
journal article
Author(s)
Cárdenas Ramírez B.
Mantilla Cruzatti O.
Rivera Romaní J.
Rondón Leyva C.
Sumire Umeres J.
Chaman Ortiz J.
Abstract
INTRODUCTION: The recurrence of autoimmune hepatitis (HAI) following liver transplantation occurs between 8-68%. In our experience, autoimmune liver diseases are a major indication of liver transplantation. OBJECTIVE: To determine the recurrence of autoimmune hepatitis in 15 years of experience and to evaluate the risk factors associated with the recurrence of HAI. MATERIALS AND METHODS: Retrospective, descriptive and cross-sectional study. From March 2000 to December 2015; 200 transplants were performed on 190 liver transplants; 36 patients were diagnosed for hepatic cirrhosis by HAI and underwent liver biopsy if transaminase (TGP-TGO >2 ULN) in 2 consecutive measurements. The diagnosis was made by histological criteria. RESULTS: The indication for hepatic transplantation for HAI was 19%. Mean age was 35 years (range 16-64 years) relationship between Sex F / M 2.2, the most common HAI subtype is type 1 (89%). The HAI histological recurrence was 31% (11/36). The mean follow-up was 54 months (range 8-169 months). CONCLUSIONS: Autoimmune hepatitis is the most frequent indication of liver transplantation in our experience, accounting for 19%. The recurrence of post-transplant HAI was 31%. No association was found between the degree of severity of histological activity in the explants and the type of HLA in the presentation of the recurrence.
Start page
44
End page
48
Volume
38
Issue
1
Language
Spanish
OCDE Knowledge area
Gastroenterología, Hepatología
Scopus EID
2-s2.0-85059084503
PubMed ID
Source
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
Sources of information: Directorio de Producción Científica Scopus