We describe a huge planetary-scale disturbance in the highest-speed Jovian jet at latitude 23.5°N that was first observed in October 2016 during the Juno perijove-2 approach. An extraordinary outburst of four plumes was involved in the disturbance development. They were located in the range of planetographic latitudes from 22.2° to 23.0°N and moved faster than the jet peak with eastward velocities in the range 155 to 175 m s−1. In the wake of the plumes, a turbulent pattern of bright and dark spots (wave number 20–25) formed and progressed during October and November on both sides of the jet, moving with speeds in the range 100–125 m s−1 and leading to a new reddish and homogeneous belt when activity ceased in late November. Nonlinear numerical models reproduce the disturbance cloud patterns as a result of the interaction between local sources (the plumes) and the zonal eastward jet.