In this study, a novel design of a second kind of nonlinear Lane–Emden prediction differential singular model (NLE-PDSM) is presented. The numerical solutions of this model were investigated via a neuro-evolution computing intelligent solver using artificial neural networks (ANNs) optimized by global and local search genetic algorithms (GAs) and the active-set method (ASM), i.e., ANN-GAASM. The novel NLE-PDSM was derived from the standard LE and the PDSM along with the details of singular points, prediction terms and shape factors. The modeling strength of ANN was implemented to create a merit function based on the second kind of NLE-PDSM using the mean squared error, and optimization was performed through the GAASM. The corroboration, valida-tion and excellence of the ANN-GAASM for three distinct problems were established through relative studies from exact solutions on the basis of stability, convergence and robustness. Furthermore, explanations through statistical investigations confirmed the worth of the proposed scheme.