The current industrial revolution., known as Industry 4.0, consists of the digitalization of industrial processes and also incorporates the use of 3D printers, autonomous vehicles, the Internet of Things (IoT), robotics, virtual reality companies, must adapt to these changes. For these reasons, the next generation of Business Engineers must strengthen their technical knowledge and personal skills to face this new digital era. In this work, different learning methods that reinforce soft or social skills focused on Integration, Trust, Communication, and Collaboration (ITC2) are shown to acquire the necessary tools to occupy the jobs and lead this virtual revolution. For this purpose, different methodologies, such as serious games, gamification, simulation and case studies are proposed for the teaching of ITC2 skills in an Engineering course. Significant improvements were made in the students' academic performance and in the continuous use of critical thinking.