BACKGROUND: Mucocutaneous lesions are common manifestations of infection with human immunodeficiency virus (HIV), occurring in more than 80% of HIV-infected patients. Skin findings may occur at any stage of the infection and tend to develop more frequently with increasing immunodeficiency. OBJECTIVES: To identify the mucocutaneous lesions predictive of CD4+ T lymphocyte count < 200 cells/l in HIVinfected patients. MATERIAL AND METHOD: We evaluated 106 HIV-positive patients, aged more than 15 years old, to determine the number and type of mucocutaneous lesions and CD4+ T cell count. Logistic regression was used to determine mucocutaneous lesions as predictors of CD4+ T cells < 200/l in HIV-infected patients. RESULTS: The mean age was 33.7 years and 69.8% were men. CD4+ T cells < 200/l were found in 69.8%. There was a difference in the number of lesions/patient in the AIDS and non-AIDS groups. The most common mucocutaneous lesions were onychomycosis (50.9%), seborrheic dermatitis (48.1%), oral candidiasis (42.5%), xerosis (40.6%), tineas (32.1%), prurigo (22.6%), diffuse hair loss (15.1%), and herpes simplex (12.3%). The most common mucocutaneous lesions with CD4+ T cells < 200/l were onychomycosis, oral candidiasis, xerosis, prurigo, and diffuse loss hair. CONCLUSIONS: The lesions predictive of CD4+ T cells <200/l in HIV-infected patients were onychomycosis, oral candidiasis, and prurigo. © 2009 Elsevier España S.L.