Title
ARFI Variance of Acceleration for Diagnostic Breast Cancer Imaging in Women, in vivo
Date Issued
01 January 2021
Access level
metadata only access
Resource Type
conference paper
Author(s)
Phillips A.V.
Steed D.
Caughey M.C.
Merhout J.
Kirk S.R.
Hartman T.S.
Kuzmiak C.M.
Ray E.M.
Gallippi C.M.
University of North Carolina
Publisher(s)
IEEE Computer Society
Abstract
Early detection of breast cancer greatly aids survival. However, the specificity of current screening methods for identifying malignancy is poor, requiring costly and invasive additional tests and causing anxiety for the patient. Although some ultrasound methods have used mechanical properties to discriminate benign and malignant lesions, they are complicated by tissue features like fluid and necrosis. We propose a new metric, ?Log(VoA), which can be calculated from ARFI ultrasound data and incorporates the mechanical and acoustic properties of tissue into one parameter. ?Log(VoA) is statistically significantly lower in fluid- and necrosis-containing masses than solid ones (Wilcoxin, p<0.006). ?Log(VoA) does not significantly differ between malignant and benign masses. However, it is significantly lower in the surrounding tissue of malignant masses than in the surrounding tissue of benign ones (Wilcoxin, p<0.02). These results suggest that ?Log(VoA) can differentiate clinically relevant lesion features such as fluid and necrosis, and detect tissue characteristics that coincide with malignancy.
Language
English
OCDE Knowledge area
Radiología, Medicina nuclear, Imágenes médicas
Tecnología médica de laboratorio (análisis de muestras, tecnologías para el diagnóstico)
Subjects
Scopus EID
2-s2.0-85122862693
ISSN of the container
19485719
Conference
IEEE International Ultrasonics Symposium, IUS
Sponsor(s)
ACKNOWLEDGMENT The authors thank the UNC Hospital Breast Imaging Division and Radiology Department for their assistance with clinical data collection. This study was supported by NIH grants R01HL092944, R01NS074057, R01DK107740, and K02HL105659, as well as the Comprehensive Cancer Center Development Grant the NCSU Provost’s Doctoral Fellowship.
Sources of information:
Directorio de Producción Científica
Scopus