Title
Impact of HLA-DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort
Date Issued
01 October 2017
Access level
metadata only access
Resource Type
journal article
Author(s)
Oriol-Tordera B.
Llano A.
Cate S.
Hildebrand W.
Sanchez J.
Calle M.L.
Brander C.
Olvera A.
Publisher(s)
Blackwell Publishing Ltd
Abstract
Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P =.044) while DRB1*12:01 showed significantly lower viral set points (P =.015) and restricted a dominant T cell response to HIV Gag p24 (P =.038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control.
Start page
234
End page
237
Volume
90
Issue
4
Language
English
OCDE Knowledge area
Inmunología
Virología
Scopus EID
2-s2.0-85021834274
PubMed ID
Source
HLA
ISSN of the container
20592302
Sponsor(s)
We thank all participants in this study and the clinical staff at IMPACTA in Lima, Peru. This project has received funding from the European Union's FP7 Program grant Cutaneous and Mucosal HIV Vaccination (CUT'HIVAC) EC-7FP-241904, the Horizon 2020 Research and Innovation Program grant European AIDS Vaccine Initiative 2020 (EAVI2020) GA681137, the HIVACAT program as well as an unrestricted gift by Rafael Punter and the Barcelona HIV Gala 2015. B.O.-T., C.B., A.O., A.L., S.C., C.G., J.S. and M.L.C. have no conflicting interests. But W.H. does declare a conflict of interest with regard to his relationship with Pure MHC. B.O.-T. performed all the statistical analysis with R software under the supervision of A.O., M.L.C. and C.B., B.O.-T., A.O. and C.B. drafted the first version of the manuscript together with A.L. S.C. and W.H. performed HLA typing. C.G. and J.S. were responsible of cohort recruitment, management and clinical data collection.
Sources of information:
Directorio de Producción Científica
Scopus