Title
An international perspective on hospitalized patients with viral community-acquired pneumonia
Date Issued
01 February 2019
Access level
open access
Resource Type
journal article
Author(s)
Radovanovic D.
Sotgiu G.
Jankovic M.
Mahesh P.A.
Marcos P.J.
Abdalla M.I.
Di Pasquale M.F.
Gramegna A.
Terraneo S.
Blasi F.
Santus P.
Aliberti S.
Reyes L.F.
Restrepo M.I.
Aruj P.K.
Attorri S.
Barimboim E.
Caeiro J.P.
Garzón M.I.
Cambursano V.H.
Ceccato A.
Chertcoff J.
Cordon Díaz A.
de Vedia L.
Ganaha M.C.
Lambert S.
Lopardo G.
Luna C.M.
Malberti A.G.
Morcillo N.
Tartara S.
Pensotti C.
Pereyra B.
Scapellato P.G.
Stagnaro J.P.
Shah S.
Lötsch F.
Thalhammer F.
Anseeuw K.
Francois C.A.
Van Braeckel E.
Vincent J.L.
Djimon M.Z.
Aranha Nouér S.
Chipev P.
Encheva M.
Miteva D.
Petkova D.
Balkissou A.D.
Pefura Yone E.W.
Mbatchou Ngahane B.H.
Shen N.
Xu J.f.
Bustamante Rico C.A.
Buitrago R.
Pereira Paternina F.J.
Kayembe Ntumba J.M.
Vladic-Carevic V.
Jakopovic M.
Matkovic Z.
Mitrecic I.
Bouchy Jacobsson M.L.
Bro Christensen A.
Bødtger U.
Meyer C.N.
Vestergaard Jensen A.
El-Said Abd El-Wahhab I.
Elsayed Morsy N.
Shafiek H.
Sobh E.
Abdulsemed K.A.
Bertrand F.
Brun-Buisson C.
de Montmollin E.
Fartoukh M.
Messika J.
Tattevin P.
Khoury A.
Ebruke B.
Dreher M.
Kolditz M.
Meisinger M.
Pletz M.W.
Hagel S.
Rupp J.
Schaberg T.
Spielmanns M.
Creutz P.
Suttorp N.
Siaw-Lartey B.
Dimakou K.
Papapetrou D.
Tsigou E.
Ampazis D.
Kaimakamis E.
Bhatia M.
Dhar R.
D'Souza G.
Garg R.
Koul P.A.
Publisher(s)
Elsevier B.V.
Abstract
Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
Start page
54
End page
70
Volume
60
Language
English
OCDE Knowledge area
Sistema respiratorio
Subjects
Scopus EID
2-s2.0-85055913331
PubMed ID
Source
European Journal of Internal Medicine
ISSN of the container
09536205
Source funding
GlaxoSmithKline Australia
Sponsor(s)
DR, GS, MJ, PAM, PJM, MIA, MFDP, AG, ST, PS, SA, LFR, MIR declare no conflict of interest in regard to this article. FB reports grants and personal fees from AstraZeneca, Bayer, Chiesi, Grifols, GSK, Guidotti-Malesci, Menarini, Novartis, Pfizer, Teva, Zambon outside the submitted work.
Sources of information:
Directorio de Producción Científica
Scopus