Title
Identification of diurnal patterns in insulin action from measured CGM data for patients with T1DM
Date Issued
16 November 2015
Access level
metadata only access
Resource Type
conference paper
Author(s)
Reiterer F.
Kirchsteiger H.
Freckmann G.
Universidad Johannes Kepler Linz
Abstract
We propose a method to identify diurnal changes in insulin action in patients suffering from type 1 diabetes mellitus (T1DM) based on data recorded by continuous glucose monitoring systems (CGMS). In order to do so the data is fitted using a continuous time transfer function including time dependent terms. The identified values for the insulin needs per gram of carbohydrate were compared with the patient-specific carbohydrate-to-insulin-ratios used for the calculation of the bolus insulin needs. A good agreement between the identified parameters and values determined by diabetologists were found. Furthermore, the diurnal variations in insulin action (as inferred from the changes in the patient-specific carbohydrate-to-insulin-ratios) could be reproduced. The identified models, including the diurnal changes in insulin action and the information on the intra-patient variability, have the potential to be used in future studies for managing the blood glucose level of patients, e.g. in a smart bolus calculator.
Start page
1
End page
6
OCDE Knowledge area
Medicina clínica Endocrinología, Metabolismo (incluyendo diabetes, hormonas)
Scopus EID
2-s2.0-84963800287
ISBN of the container
9783952426937
Conference
2015 European Control Conference, ECC 2015
Sources of information: Directorio de Producción Científica Scopus