Diseases caused by Moniliophthora roreri (moniliasis), Crinipellis perniciosa (witches' broom) and Phytophthora palmivora (black pod) are the most important factors limiting cocoa production in Peru and cultural management is considered to be the only practical means of control for the smallholder. The objective of this study was to develop an epidemiologically and economically sound control recommendation based on the frequency of phytosanitary pod removal. Weekly removal of diseased pods reduced the incidence of diseases significantly in comparison with fortnightly removal. In three fields, moniliasis was decreased by 26-41%, black pod by 35-66% and witches' broom on pods by 14-57%. The cumulative effect was a consistent yield increase from an average of 504-660 kg ha-1 yr-1. Returns compensated for increased labour costs. Weekly pod removal was 32% more profitable. Time-course analyses indicated that weekly removal should be practised throughout the year under field conditions of eastern Peru.