Kiwicha (Amaranthus cuadatus L.) is an alternative source of protein of vegetable origin, grown mostly in temporary and with low yields, so it is important to develop efficient management practices of varieties and fertilization levels to increase their productivity. The study was conducted with the objective of determining the interaction of two varieties of kiwicha (Oscar Blanco, Centenario) and the Caracino ecotype with three levels of fertilization (NPK), under a Randomized Complete Block Design (DBCA) with a factorial arrangement 3V x 3F and four repetitions in conditions of the town of Mato province of Huaylas, Ancash. The variables under study were: plant height, days of flowering, and days of maturation, weight of a thousand grains, yield and protein content. With the dose of 120-100-80 the highest values were found for yield, plant height and number of days at maturation, with 2105.58 kg ha-1, 90.50 cm and 123.83 days, respectively; while with the dose 18-46-30 in weight of one thousand grains and protein content with 1.12 g and 20.19%, respectively. The Centennial variety resulted in the highest values for yield and weight of 1000 grains with 2104.75 and 1.09 g; while in protein content the Caracino ecotype with 20.01% was higher compared to Oscar Blanco (18.72%) and Centenario (18.35%).