Title
Invited Article: Experimental evaluation of gold nanoparticles as infrared scatterers for advanced cardiovascular optical imaging
Date Issued
01 August 2018
Access level
open access
Resource Type
journal article
Author(s)
Hu J.
Romero Abujetas D.
Tsoutsi D.
Leggio L.
Rivero F.
Martín Rodríguez E.
Aguilar Torres R.
Sánchez-Gil J.A.
Gallego D.
Lamela Rivera H.
Rivera Gil P.
Alfonso F.
García Solé J.
Jaque D.
Publisher(s)
American Institute of Physics
Abstract
The tremendous impact that cardiovascular diseases have in modern society is motivating the research of novel imaging techniques that would make possible early diagnosis and, therefore, efficient treatments. Cardiovascular optical coherence tomography (CV-OCT) emerged as a result of such a demand, and it has already been used at the clinical level. Full utilization of CV-OCT requires the development of novel contrast molecular agents characterized by a large scattering efficiency in the infrared (800-1400 nm). Gold nanoparticles (GNPs) seem to be the best candidates, but their scattering properties in the infrared are hardly known. In most of the cases, scattering properties are extracted from numerical simulations. This knowledge gap here is covered by providing an experimental evaluation of the infrared scattering properties of different GNPs (nanoshells, nanostars, and nanorods). These GNPs display remarkable extinction coefficients in the first and second biological windows, including the particular CV-OCT wavelength. We use a unique combination of techniques (thermal loading experiments, infrared optical coherence tomography, infrared dark field microscopy, and optoacoustic spectroscopy) to experimentally determine the scattering efficiency at three different near-infrared wavelengths (808 nm, 980 nm, and 1280 nm), lying in the first and second biological windows. Consequently, this work determines experimentally the influence of particle morphology on the infrared scattering efficiency of GNPs and evidences the existence of remarkable discrepancies between experimental data and numerical simulations.
Volume
3
Issue
8
Language
English
OCDE Knowledge area
Sistema cardiaco, Sistema cardiovascular
Nano-materiales
Scopus EID
2-s2.0-85055401902
Source
APL Photonics
ISSN of the container
23780967
Sources of information:
Directorio de Producción Científica
Scopus