The first prototype of an adaptive wiring panel was recently introduced that implemented a reconfigurable switch fabric that allows dynamic routing of analog, digital, and power signals for space system applications. In this paper, a complete redesign and reimplementation of the adaptive wiring panel system is considered to address issues associated with scalability, reliability, and real-time monitoring of the switching fabric. The new system is demonstrated using 48 cells as opposed to the six cells of the first adaptive wiring panel prototype. The hardware and software systems are open source, and recommendations are provided to support further extensions to the system. Copyright © 2013 by the American Institute of Aeronautics and Astronautics, Inc. All rights reserved.