Title
A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents
Date Issued
01 December 2015
Access level
open access
Resource Type
journal article
Author(s)
Carpenter C.
Sidney J.
Kolla R.
Nayak K.
Tomiyama H.
Tomiyama C.
Padilla O.A.
Rozot V.
Ahamed S.F.
Ponte C.
Rolla V.
Antas P.R.
Chandele A.
Kenneth J.
Laxmi S.
Makgotlho E.
Vanini V.
Ippolito G.
Kazanova A.S.
Panteleev A.V.
Hanekom W.
Mayanja-Kizza H.
Lewinsohn D.
McElrath M.J.
Boom W.H.
Goletti D.
Lyadova I.V.
Scriba T.J.
Kallas E.G.
Murali-Krishna K.
Sette A.
Lindestam Arlehamn C.S.
Publisher(s)
Churchill Livingstone
Abstract
We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.
Start page
713
End page
721
Volume
95
Issue
6
Language
English
OCDE Knowledge area
Epidemiología
Biología celular, Microbiología
Inmunología
Subjects
Scopus EID
2-s2.0-84948718070
PubMed ID
Source
Tuberculosis
ISSN of the container
14729792
Sponsor(s)
This work was supported by the National Institutes of Health [contract HHSN272200900044C to A.S., contract HHSN266200700022C/NO1-AI-70022 to W.H.B, grant R37AI052731 to E.G.K]: the IOC/FIOCRUZ [CNPq research fellowship PQ-2-Brazil to P.R.A.]: The Italian Ministry of Health [Ricerca Corrente to D.G.], the Bill and Melinda Gates Foundation [ OPP1066265 to T.J.S.], and the HIV Vaccine Trials Network [RAMP scholarship to O.A.P.], the Russian Science Foundation [ 15-15-00136 to I.V.L.]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Sources of information:
Directorio de Producción Científica
Scopus