The purpose of this communication is to present two cases of Chagas' disease in a familial group of a index case, coming from the Arequipa region in southwestern Peru, an endemic area. The case suffered sudden death because ofchagasic cardiomyopathy in an area free triatomines in Department lea. His sister and his nephew showed IgG specific antibodies anti - Trypanosoma cruzi detected by enzime-linked immunosorbent assay (EL1SA) and indirect immunofluorescence assay (IFA), both households had lived in an endemic valley (Vitor-Arequipa). Our results underscore the importance of the epidemiological survey in the familial group of the chronic case in low risk-areas.