To determine the frequency of pancreas solid-pseudopapillary tumor (SPT) and to describe its clinical, pathological and immunohistochemical features in the National Institute of Neoplasic Diseases (INEN). Cross-sectional, Retrospective and Descriptive study of 28 SPT cases with clinic history, slides and paraffin blocks for the revision and inmunohistochemical examination. Tissue Microarray technique was used and avidin-biotin method in the necessary cases. The statistical processing was made with SPSS 13.0 program. The SPT accounts for 3.7% of pancreatic tumors in the INEN. 24 patients were female (85.7%) and 4 male (14.3%) with average age 25.61years old. Clinically 50% displayed abdominal pain. There was no Ca 19-9 abnormal value. Two metastasis cases were found, one of them died. The average tumor size was 10.0 cm. and the most frequent location was the head of the pancreas. Histologically is a monoforme pattern neoplasia, that displays pseudopapillae, rosettes, cholesterol crystals, sclerosis and calcification. The vascular infiltration, perineural, mitosis and nuclear atipia appeared in malignant cases. Immunohistochemically were vimentin and progesterone positive in the most cases. SPT is uncommon tumor with clinical, pathological and inmunohistochemical defined features. It is less aggressive than other pancreatic tumors, nevertheless its uncertain behavior demands follow up.