Title
Evolutionary decision rules for predicting protein contact maps
Date Issued
16 October 2014
Access level
open access
Resource Type
journal article
Author(s)
Universidad de Pablo de Olavide
Publisher(s)
Springer London
Abstract
Protein structure prediction is currently one of the main open challenges in Bioinformatics. The protein contact map is an useful, and commonly used, representation for protein 3D structure and represents binary proximities (contact or non-contact) between each pair of amino acids of a protein. In this work, we propose a multi-objective evolutionary approach for contact map prediction based on physico-chemical properties of amino acids. The evolutionary algorithm produces a set of decision rules that identifies contacts between amino acids. The rules obtained by the algorithm impose a set of conditions based on amino acid properties to predict contacts. We present results obtained by our approach on four different protein data sets. A statistical study was also performed to extract valid conclusions from the set of prediction rules generated by our algorithm. Results obtained confirm the validity of our proposal.
Start page
725
End page
737
Volume
17
Issue
4
Language
English
OCDE Knowledge area
Bioinformática
Subjects
Scopus EID
2-s2.0-84919490619
Source
Pattern Analysis and Applications
ISSN of the container
14337541
Sources of information:
Directorio de Producción Científica
Scopus