To formulate economically viable foods and achieve high performance in Guinea pig production, it is important to know the nutritional value of the feeds, which requires determining their chemical composition, availability of nutrients, and energy content. Chemical analysis, digestibility tests, and digestible energy (DE) and metabolizable energy (ME) content of 63 feeds were determined using male Guinea pigs of 4-5 mo of age. The test feeds were fodder, agricultural residues, agro-industrial and kitchen waste, energy flours, and protein flours of animal and vegetable origin. The result showed wide variability in the chemical composition and energy density of the feeds evaluated. In the case of forages, the main feed source for the Guinea pigs, the average contents ± SD of crude protein (CP), crude fiber (CF), organic matter (OM), DE, and ME were 18.06 ± 6.50%, 23.08 ± 7.14%, 89.95 ± 2.62%, 2963.71 ± 442.68, and 2430.24 ± 363.00 kcal/kg; for the agro-industrial and kitchen waste, the values were 11.52 ± 4.72%, 22.80 ± 14.61%, 91.37 ± 4.74%, 3006.31 ± 554.01, and 2465.18 ± 454.29 kcal/kg; for protein feeds, the values were 55.18 ± 22.87%, 5.11 ± 5.72%, 91.18 ± 6.92%, 3681.94 ± 433. 24, and 3019.19 ± 355.26 kcal/kg; for energy feeds, the values were 12.73 ± 3.22%, 5.46 ± 1.96%, 95.33 ± 3.32%, 3705.41 ± 171.78, and 3038.43 ± 140.86 kcal/ kg. The ME content is directly associated with CP content (R2 = 0.19) and OM digestibility (R2 = 0.56) and inversely with CF (R2 = 0.40) and ash (R2 = 0.13) content (P < 0.01). The results of this study can be used to design feeding programs for family and commercial Guinea pig production for meat.