Objective. To demonstrate the protective effect of Sacha inchi oil (SI) in arthritis induced by carrageenan in Holtzman rats. Methods. Quantitative, experimental and correlational study; 30 rats, males, randomly distributed in 5 groups were used: 1) SSF 2 mL/kg; 2) Carrageenan; 3) 4) and 5) Sacha inchi. Except for the control, they received 0.1 mL 2% carrageenan intra-articularly (the area of the femur joint with the left tibia); sacha inchi oil orally 225, 1125 and 2250 mg/kg correspondingly; determining time (seconds), type of grip (normal, poor, regular, moderate, intense), and pannus inflammation, pannus fibrosis by means of histopathological study. Applying analysis of variance, Tukey and Fisher test. Results. There was a higher percentage of dose-dependent anti-inflammatory effect and grasp time at 2250 mg/Kg, followed by 1125 mg/Kg; and the histopathological study showed mild pannus and absent fibrosis with the highest dose, in contrast to doses of 1125 mg/Kg of oil there was moderate pannus, and mild fibrosis. Conclusions. The protective effect of Sacha inchi oil (SI) has demonstrated by increasing the time and improving the type of grasp and reducing the pannus in arthritis induced by carrageenan in Holtzman rats.