We are currently witnessing a constant and ongoing change of the epidemiological pictures of yeast resistance to antifungal agents, related to the type of host, etiology of the disease, the microorganism involved, and its mechanisms of resistance. This epidemiological situation complicates management of patients with infections of the bloodstream due to species of the genus Candida, exhibiting a high mortality and an increase in the use of anti-fungal agents, as well as the need to develop reliable methods to conduct sensitivity studies. Therefore, local and regional monitoring is important in order to know the sensitivity profile and the distribution of Candida species so as to start an adequate anti-fungal therapy.