Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic. Many infected clusters have been found within family households, but data on secondary transmission among household contacts are limited. The evolution of the epidemiological situation has shown that social distancing, the application of personal protective equipment and remote activities at home are effective measures to stop the transmission of the virus; and the last of these is gaining increasing importance due to the isolation of SARS-CoV-2 positive patients in their homes. The objective of this study is to compare the effect of the integration of home automation elements in houses with positive patients in isolation with Covid-19 and conventional houses without any remote element, understanding that the least contact with surfaces, objects and areas are important to prevent the spread. In relation to Social Isolation and Remote Activity, the frequency percentages were very similar; while in the Protection Measures, the smart house with older adults presented a lower percentage of frequency compared to the conventional house and the smart house with contemporary adults. Our data provide information on the rate of secondary transmission of SARS-CoV-2 in the home and the effect of the inclusion of home automation elements to prevent contagion.