Title
Pulmonary aspergillosis Due to methimazole-induced neutropenia: A case report
Other title
Aspergilosis pulmonar Secundaria a neutropenia inducida por metimazol: Reporte de un caso
Date Issued
01 January 2012
Access level
open access
Resource Type
journal article
Author(s)
Pinto M.E.
Banda C.
SEAS RAMOS, CARLOS RAFAEL
Publisher(s)
Instituto Nacional de Salud
Abstract
A 48-year old woman with a recent diagnosis of Graves' disease arrived at the emergency room with fever, palpitations, and a sore throat. Her regular treatment included methimazole. On admission, laboratory results showed suppressed TSH, elevated free thyroxine, and neutropenia. She was admitted and started on antibiotics and granulocyte-macrophage colony stimulating factor (gm-csf). After ten days, the patient developed leukocytosis, fever, and hemoptysis. Chest CT scan showed a lung cavity with multiple nodules in the upper right lobe. Cultures from a lung biopsy were positive for Aspergillus Fumigatus and Aspergillus Flavus. Amphotericin B was started but then switched to voriconazole, with both treatments failing to result in clinical improvement. The patient died of multi-organ failure.
Start page
255
End page
258
Volume
29
Issue
2
Language
English
OCDE Knowledge area
Medicina general, Medicina interna
Scopus EID
2-s2.0-84866879033
Source
Revista Peruana de Medicina Experimental y Salud Publica
ISSN of the container
17264634
Sources of information: Directorio de Producción Científica Scopus