Title
Pulmonary aspergillosis Due to methimazole-induced neutropenia: A case report
Other title
Aspergilosis pulmonar Secundaria a neutropenia inducida por metimazol: Reporte de un caso
Date Issued
01 January 2012
Access level
open access
Resource Type
journal article
Publisher(s)
Instituto Nacional de Salud
Abstract
A 48-year old woman with a recent diagnosis of Graves' disease arrived at the emergency room with fever, palpitations, and a sore throat. Her regular treatment included methimazole. On admission, laboratory results showed suppressed TSH, elevated free thyroxine, and neutropenia. She was admitted and started on antibiotics and granulocyte-macrophage colony stimulating factor (gm-csf). After ten days, the patient developed leukocytosis, fever, and hemoptysis. Chest CT scan showed a lung cavity with multiple nodules in the upper right lobe. Cultures from a lung biopsy were positive for Aspergillus Fumigatus and Aspergillus Flavus. Amphotericin B was started but then switched to voriconazole, with both treatments failing to result in clinical improvement. The patient died of multi-organ failure.
Start page
255
End page
258
Volume
29
Issue
2
Language
English
OCDE Knowledge area
Medicina general, Medicina interna
Scopus EID
2-s2.0-84866879033
Source
Revista Peruana de Medicina Experimental y Salud Publica
ISSN of the container
17264634
Sources of information: Directorio de Producción Científica Scopus