The Hippocrateaceae are represented in Peru by nine genera and 52 species (Brako & Zarucchi, 1993; Ulloa Ulloa et al., 2004), mostly lianas. Here we recognize three endemic species in the same number of genera. These endemic species are found in the Humid Lowland Amazonian Forests region, between 100 and 135 m elevation. We applied IUCN categories and criteria to two species. No endemic Hippocrateaceae have been registered to date in Peru's protected areas system.